STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DM42_2737Dna segregation atpase ftsk/spoiiie, s-dna-t family; Belongs to the FtsK/SpoIIIE/SftA family (1519 aa)    
Predicted Functional Partners:
polA
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
 
 
 0.831
DM42_1684
Parb family transcriptional regulator, chromosome partitioning protein; Belongs to the ParB family
 
  
 0.806
ftsW
Cell division protein ftsw; Peptidoglycan polymerase that is essential for cell division
 
  
 0.713
ftsA
Cell division protein ftsa; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
  
 
 
 0.702
ftsL
Cell division protein ftsl; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
    
 
 0.666
dnaA
Chromosomal replication initiator protein dnaa; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids
  
 
 0.644
flgK
flgK_ends: flagellar hook-associated protein FlgK
      
 0.636
greA
Transcription elongation factor grea domain protein; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
 
    0.629
DM42_7406
Parb family transcriptional regulator, chromosome partitioning protein; Belongs to the ParB family
 
   
 0.612
DM42_2977
comEC_Rec2: DNA internalization-related competence protein ComEC/Rec2
 
   
 0.605
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
Server load: low (7%) [HD]