Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WI67_12585
annotation not available (126 aa)
Predicted Functional Partners:
DM42_2740
Conserved hypothetical protein
0.636
WL94_01095
annotation not available
0.607
WL94_30075
Uncharacterized protein
0.600
WL94_01160
annotation not available
0.577
DM42_3108
annotation not available
0.574
DM42_3029
annotation not available
0.561
WL94_29795
annotation not available
0.555
WL94_24550
annotation not available
0.549
purT
Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
DM42_2740
DM42_3029
DM42_2740
DM42_3029
Conserved hypothetical protein
annotation not available
0.453
DM42_2740
WI67_12585
DM42_2740
DM42_2741
Conserved hypothetical protein
annotation not available
0.636
DM42_2740
WL94_24550
DM42_2740
DM42_2738
Conserved hypothetical protein
annotation not available
0.565
DM42_2740
WL94_29795
DM42_2740
DM42_3463
Conserved hypothetical protein
annotation not available
0.418
DM42_2740
purT
DM42_2740
DM42_2739
Conserved hypothetical protein
Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family
0.792
DM42_3029
DM42_2740
DM42_3029
DM42_2740
annotation not available
Conserved hypothetical protein
0.453
DM42_3029
DM42_3108
DM42_3029
DM42_3108
annotation not available
annotation not available
0.766
DM42_3029
WI67_11060
DM42_3029
DM42_3062
annotation not available
Uncharacterized protein
0.726
DM42_3029
WI67_12585
DM42_3029
DM42_2741
annotation not available
annotation not available
0.561
DM42_3029
WL94_01095
DM42_3029
DM42_5140
annotation not available
annotation not available
0.740
DM42_3029
WL94_01160
DM42_3029
DM42_5127
annotation not available
annotation not available
0.703
DM42_3029
WL94_24550
DM42_3029
DM42_2738
annotation not available
annotation not available
0.591
DM42_3029
WL94_29795
DM42_3029
DM42_3463
annotation not available
annotation not available
0.748
DM42_3029
WL94_30075
DM42_3029
DM42_3407
annotation not available
Uncharacterized protein
0.742
DM42_3108
DM42_3029
DM42_3108
DM42_3029
annotation not available
annotation not available
0.766
DM42_3108
WI67_11060
DM42_3108
DM42_3062
annotation not available
Uncharacterized protein
0.697
DM42_3108
WI67_12585
DM42_3108
DM42_2741
annotation not available
annotation not available
0.574
DM42_3108
WL94_01095
DM42_3108
DM42_5140
annotation not available
annotation not available
0.771
DM42_3108
WL94_01160
DM42_3108
DM42_5127
annotation not available
annotation not available
0.707
DM42_3108
WL94_24550
DM42_3108
DM42_2738
annotation not available
annotation not available
0.549
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Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) explain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: