STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate (338 aa)    
Predicted Functional Partners:
ilvN
Acolac_sm: acetolactate synthase, small subunit
 
 0.997
ilvB
Acolac_lg: acetolactate synthase, large subunit, biosynthetic type
 
 
 0.996
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family
 
 0.994
IlvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family
 
 0.992
ilvD_6
Dehydratase family protein; Belongs to the IlvD/Edd family
 
 0.986
DM42_1639
Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family
 
 
 0.969
DM42_4269
Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family
 
 
 0.959
DM42_6104
Thiamine pyrophosphate enzyme, central domain protein; Belongs to the TPP enzyme family
 
 
 0.955
leuC
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate
 
  
 0.927
pheA
Chorismate mutase / prephenate dehydratase; CM_P2: chorismate mutase
 
 
 0.907
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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