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ilvC protein (Burkholderia cepacia) - STRING interaction network
"ilvC" - Ketol-acid reductoisomerase in Burkholderia cepacia
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ilvCKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (338 aa)    
Predicted Functional Partners:
ilvN
Acolac_sm- acetolactate synthase, small subunit (163 aa)
 
  0.998
WL94_04345
ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family (557 aa)
 
  0.996
WI67_22900
ilvD- dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family (619 aa)
 
  0.995
ilvB
Acolac_lg- acetolactate synthase, large subunit, biosynthetic type (587 aa)
 
 
  0.992
WL94_03370
annotation not available (567 aa)
 
 
  0.965
WL94_27150
annotation not available (546 aa)
 
 
  0.957
WI67_27090
annotation not available (555 aa)
 
 
  0.954
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (355 aa)
 
   
  0.902
pheA
CM_P2- chorismate mutase (360 aa)
 
 
  0.893
WI67_32145
annotation not available (583 aa)
 
 
  0.881
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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