node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DM42_4992 | WI67_12270 | DM42_4992 | DM42_2802 | ac_ald_DH_ac: acetaldehyde dehydrogenase | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | 0.949 |
DM42_4992 | WL94_05875 | DM42_4992 | DM42_6344 | ac_ald_DH_ac: acetaldehyde dehydrogenase | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds | 0.802 |
WI67_12270 | DM42_4992 | DM42_2802 | DM42_4992 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | ac_ald_DH_ac: acetaldehyde dehydrogenase | 0.949 |
WI67_12270 | WI67_22900 | DM42_2802 | DM42_3831 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | 0.971 |
WI67_12270 | WL94_04345 | DM42_2802 | DM42_2606 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | 0.978 |
WI67_12270 | WL94_05875 | DM42_2802 | DM42_6344 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds | 0.949 |
WI67_12270 | WL94_39140 | DM42_2802 | DM42_5889 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | annotation not available | 0.932 |
WI67_12270 | ilvB | DM42_2802 | DM42_2797 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | Acolac_lg: acetolactate synthase, large subunit, biosynthetic type | 0.937 |
WI67_12270 | ilvE | DM42_2802 | DM42_2438 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family | 0.960 |
WI67_12270 | leuB | DM42_2802 | DM42_4101 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate | 0.918 |
WI67_12270 | leuC | DM42_2802 | DM42_4103 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily | 0.992 |
WI67_12270 | leuD | DM42_2802 | DM42_4102 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the LeuD family. LeuD type 1 subfamily | 0.979 |
WI67_22900 | WI67_12270 | DM42_3831 | DM42_2802 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily | 0.971 |
WI67_22900 | WL94_04345 | DM42_3831 | DM42_2606 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | 0.809 |
WI67_22900 | WL94_39140 | DM42_3831 | DM42_5889 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | annotation not available | 0.936 |
WI67_22900 | ilvB | DM42_3831 | DM42_2797 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | Acolac_lg: acetolactate synthase, large subunit, biosynthetic type | 0.891 |
WI67_22900 | ilvE | DM42_3831 | DM42_2438 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family | 0.950 |
WI67_22900 | leuB | DM42_3831 | DM42_4101 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate | 0.816 |
WI67_22900 | leuC | DM42_3831 | DM42_4103 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily | 0.839 |
WI67_22900 | leuD | DM42_3831 | DM42_4102 | ilvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the LeuD family. LeuD type 1 subfamily | 0.755 |