node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DM42_4598 | WI67_11510 | DM42_4598 | DM42_2962 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily | 0.881 |
DM42_4598 | hscA | DM42_4598 | DM42_2966 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | Chaperone protein HscA homolog; Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB | 0.907 |
DM42_4598 | hscB | DM42_4598 | DM42_2965 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | Co-chaperone protein HscB homolog; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA | 0.911 |
DM42_4598 | iscA | DM42_4598 | DM42_2964 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | iscA: iron-sulfur cluster assembly protein IscA; Belongs to the HesB/IscA family | 0.820 |
DM42_4598 | iscU | DM42_4598 | DM42_2963 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | Iron-sulfur cluster assembly scaffold protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters | 0.919 |
DM42_4598 | iscX | DM42_4598 | DM42_2968 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | iscX_yfhJ: FeS assembly protein IscX | 0.925 |
WI67_11485 | WI67_11510 | DM42_2967 | DM42_2962 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily | 0.905 |
WI67_11485 | hscA | DM42_2967 | DM42_2966 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | Chaperone protein HscA homolog; Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB | 0.962 |
WI67_11485 | hscB | DM42_2967 | DM42_2965 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | Co-chaperone protein HscB homolog; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA | 0.947 |
WI67_11485 | iscA | DM42_2967 | DM42_2964 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | iscA: iron-sulfur cluster assembly protein IscA; Belongs to the HesB/IscA family | 0.873 |
WI67_11485 | iscR | DM42_2967 | DM42_2961 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | iscR: iron-sulfur cluster assembly transcription factor IscR | 0.462 |
WI67_11485 | iscU | DM42_2967 | DM42_2963 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | Iron-sulfur cluster assembly scaffold protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters | 0.938 |
WI67_11485 | iscX | DM42_2967 | DM42_2968 | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | iscX_yfhJ: FeS assembly protein IscX | 0.984 |
WI67_11510 | DM42_4598 | DM42_2962 | DM42_4598 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | 0.881 |
WI67_11510 | WI67_11485 | DM42_2962 | DM42_2967 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily | Fdx_isc: ferredoxin, 2Fe-2S type, ISC system | 0.905 |
WI67_11510 | hscA | DM42_2962 | DM42_2966 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily | Chaperone protein HscA homolog; Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB | 0.859 |
WI67_11510 | hscB | DM42_2962 | DM42_2965 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily | Co-chaperone protein HscB homolog; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA | 0.959 |
WI67_11510 | iscA | DM42_2962 | DM42_2964 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily | iscA: iron-sulfur cluster assembly protein IscA; Belongs to the HesB/IscA family | 0.861 |
WI67_11510 | iscR | DM42_2962 | DM42_2961 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily | iscR: iron-sulfur cluster assembly transcription factor IscR | 0.960 |
WI67_11510 | iscU | DM42_2962 | DM42_2963 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily | Iron-sulfur cluster assembly scaffold protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters | 0.996 |