STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alkA_2annotation not available (275 aa)    
Predicted Functional Partners:
DM42_4668
Ogt: methylated-DNA-[]-cysteine S-methyltransferase family protein
 
 
 0.932
DM42_1804
DNA-3-methyladenine glycosylase II; 3-methyladenine DNA glycosylase 2; alkA N-terminal domain protein
  
  
  0.839
DM42_4667
Arac family transcriptional regulator, regulatory protein of adaptative response / dna-3-methyladenine glycosylase ii; alkA N-terminal domain protein
  
 
 0.829
cysS
Cysteinyl-trna synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family
  
    0.815
accA
Acetyl-coa carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
       0.718
tilS
Trna(ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
       0.658
DM42_3008
annotation not available
 
    0.647
polA
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
  
 
 0.645
ada
Arac family transcriptional regulator, regulatory protein of adaptative response / methylated-dna-[protein]-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated
 
 
 0.598
DM42_3013
Aspartate kinase, monofunctional class; Belongs to the aspartokinase family
       0.521
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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