Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DM42_3138
annotation not available (136 aa)
Predicted Functional Partners:
WI67_05240
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
DM42_3136
DM42_3137
DM42_3136
DM42_3137
annotation not available
annotation not available
0.644
DM42_3136
DM42_3138
DM42_3136
DM42_3138
annotation not available
annotation not available
0.456
DM42_3137
DM42_3136
DM42_3137
DM42_3136
annotation not available
annotation not available
0.644
DM42_3137
DM42_3138
DM42_3137
DM42_3138
annotation not available
annotation not available
0.694
DM42_3138
DM42_3136
DM42_3138
DM42_3136
annotation not available
annotation not available
0.456
DM42_3138
DM42_3137
DM42_3138
DM42_3137
annotation not available
annotation not available
0.694
DM42_3138
WI67_05240
DM42_3138
DM42_745
annotation not available
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
0.732
DM42_3138
WL94_19695
DM42_3138
DM42_2895
annotation not available
annotation not available
0.532
WI67_05240
DM42_3138
DM42_745
DM42_3138
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
annotation not available
0.732
WL94_19695
DM42_3138
DM42_2895
DM42_3138
annotation not available
annotation not available
0.532
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) explain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: