holB protein (Burkholderia cepacia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

holB

holB- DNA polymerase III, delta’ subunit (342 aa)

Predicted Functional Partners:

dnaN

0.984

tmk

0.976

holA

0.974

polA

0.973

dnaX

0.968

WL94_24515

0.949

WL94_04330

0.937

WI67_04835

0.910

mltG

0.883

dnaQ

0.857

Your Current Organism:

Burkholderia cepacia

NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
WI67_04835	WL94_04330	DM42_827	DM42_2603	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	annotation not available	0.853
WI67_04835	WL94_24515	DM42_827	DM42_2745	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	Polc- DNA polymerase III, alpha subunit	0.964
WI67_04835	dnaN	DM42_827	DM42_1785	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3’-5’ exonuclease proofreading activity. The beta chain is required for initiation of replication as [...]	0.963
WI67_04835	dnaQ	DM42_827	DM42_437	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3’-5’ exonuclease	0.822
WI67_04835	dnaX	DM42_827	DM42_3273	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	dnaX_nterm- DNA polymerase III, subunit gamma and tau	0.961
WI67_04835	holA	DM42_827	DM42_1187	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	holA- DNA polymerase III, delta subunit	0.867
WI67_04835	holB	DM42_827	DM42_3209	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	holB- DNA polymerase III, delta’ subunit	0.910
WI67_04835	polA	DM42_827	DM42_4183	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.968
WL94_04330	WI67_04835	DM42_2603	DM42_827	annotation not available	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	0.853
WL94_04330	WL94_24515	DM42_2603	DM42_2745	annotation not available	Polc- DNA polymerase III, alpha subunit	0.906
WL94_04330	dnaN	DM42_2603	DM42_1785	annotation not available	Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3’-5’ exonuclease proofreading activity. The beta chain is required for initiation of replication as [...]	0.920
WL94_04330	dnaQ	DM42_2603	DM42_437	annotation not available	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3’-5’ exonuclease	0.873
WL94_04330	dnaX	DM42_2603	DM42_3273	annotation not available	dnaX_nterm- DNA polymerase III, subunit gamma and tau	0.928
WL94_04330	holA	DM42_2603	DM42_1187	annotation not available	holA- DNA polymerase III, delta subunit	0.956
WL94_04330	holB	DM42_2603	DM42_3209	annotation not available	holB- DNA polymerase III, delta’ subunit	0.937
WL94_04330	polA	DM42_2603	DM42_4183	annotation not available	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.806
WL94_24515	WI67_04835	DM42_2745	DM42_827	Polc- DNA polymerase III, alpha subunit	Dnaq- exonuclease, DNA polymerase III, epsilon subunit family domain protein	0.964
WL94_24515	WL94_04330	DM42_2745	DM42_2603	Polc- DNA polymerase III, alpha subunit	annotation not available	0.906
WL94_24515	dnaN	DM42_2745	DM42_1785	Polc- DNA polymerase III, alpha subunit	Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3’-5’ exonuclease proofreading activity. The beta chain is required for initiation of replication as [...]	0.989
WL94_24515	dnaQ	DM42_2745	DM42_437	Polc- DNA polymerase III, alpha subunit	DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3’-5’ exonuclease	0.961

page 1 of 5

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2019

Credits

Access

Info

About