ndk protein (Burkholderia cepacia) - STRING interaction network

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ndk

Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (141 aa)

Predicted Functional Partners:

adk

0.960

dut

0.959

cmk

0.955

pyrG

0.942

dcd

0.940

rpoB

0.939

gmk

0.938

rpoA

0.936

pyrH

0.935

pnp

0.935

Your Current Organism:

Burkholderia cepacia

NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
adk	cmk	DM42_2520	DM42_781	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	0.425
adk	dut	DM42_2520	DM42_2552	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	Deoxyuridine 5’-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family	0.504
adk	gmk	DM42_2520	DM42_837	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP	0.405
adk	ndk	DM42_2520	DM42_3285	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	0.960
adk	pnp	DM42_2520	DM42_2808	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction	0.953
adk	rpoA	DM42_2520	DM42_1447	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	0.734
adk	rpoB	DM42_2520	DM42_1481	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	0.466
cmk	adk	DM42_781	DM42_2520	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	0.425
cmk	gmk	DM42_781	DM42_837	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP	0.638
cmk	ndk	DM42_781	DM42_3285	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	0.955
cmk	pnp	DM42_781	DM42_2808	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction	0.927
cmk	pyrG	DM42_781	DM42_2979	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	0.503
cmk	pyrH	DM42_781	DM42_3081	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP	0.927
cmk	rpoA	DM42_781	DM42_1447	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	0.549
cmk	rpoB	DM42_781	DM42_1481	Cmk- cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	0.406
dcd	dut	DM42_2636	DM42_2552	dCTP_deam- deoxycytidine triphosphate deaminase; Belongs to the dCTP deaminase family	Deoxyuridine 5’-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family	0.933
dcd	ndk	DM42_2636	DM42_3285	dCTP_deam- deoxycytidine triphosphate deaminase; Belongs to the dCTP deaminase family	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	0.940
dcd	rpoA	DM42_2636	DM42_1447	dCTP_deam- deoxycytidine triphosphate deaminase; Belongs to the dCTP deaminase family	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	0.901
dcd	rpoB	DM42_2636	DM42_1481	dCTP_deam- deoxycytidine triphosphate deaminase; Belongs to the dCTP deaminase family	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	0.902
dut	adk	DM42_2552	DM42_2520	Deoxyuridine 5’-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family	0.504

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