node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DM42_1245 | DM42_4848 | DM42_1245 | DM42_4848 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | 0.800 |
DM42_1245 | adk | DM42_1245 | DM42_2520 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | 0.924 |
DM42_1245 | cmk | DM42_1245 | DM42_781 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | Cmk: cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily | 0.922 |
DM42_1245 | dut | DM42_1245 | DM42_2552 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | Dutp diphosphatase family protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | 0.832 |
DM42_1245 | gmk | DM42_1245 | DM42_837 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | 0.922 |
DM42_1245 | ndk | DM42_1245 | DM42_3285 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.930 |
DM42_1245 | pyrH | DM42_1245 | DM42_3081 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP | 0.923 |
DM42_1245 | tmk | DM42_1245 | DM42_3208 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis | 0.948 |
DM42_4848 | DM42_1245 | DM42_4848 | DM42_1245 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | 0.800 |
DM42_4848 | adk | DM42_4848 | DM42_2520 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | 0.924 |
DM42_4848 | cmk | DM42_4848 | DM42_781 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Cmk: cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily | 0.922 |
DM42_4848 | dut | DM42_4848 | DM42_2552 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Dutp diphosphatase family protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | 0.832 |
DM42_4848 | gmk | DM42_4848 | DM42_837 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | 0.922 |
DM42_4848 | ndk | DM42_4848 | DM42_3285 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Nucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.930 |
DM42_4848 | tmk | DM42_4848 | DM42_3208 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis | 0.948 |
adk | DM42_1245 | DM42_2520 | DM42_1245 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | 0.924 |
adk | DM42_4848 | DM42_2520 | DM42_4848 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | 0.924 |
adk | cmk | DM42_2520 | DM42_781 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | Cmk: cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily | 0.469 |
adk | dut | DM42_2520 | DM42_2552 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | Dutp diphosphatase family protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | 0.505 |
adk | gmk | DM42_2520 | DM42_837 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | 0.665 |