Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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proteins of unknown 3D structure

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Score

DM42_3316

ribD C-terminal domain protein (177 aa)

Predicted Functional Partners:

polA

0.720

thyA

0.663

ribD

0.594

DM42_1084

0.558

DM42_3315

0.549

ung

0.457

dnaN

0.440

DM42_4848

0.416

WL94_35110

0.416

Your Current Organism:

Burkholderia cepacia

NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DM42_1084	DM42_3316	DM42_1084	DM42_3316	annotation not available	ribD C-terminal domain protein	0.558
DM42_1084	polA	DM42_1084	DM42_4183	annotation not available	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.804
DM42_1084	ribD	DM42_1084	DM42_881	annotation not available	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5’-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5’-phosphate; In the C-terminal section; belongs to the HTP reductase family	0.803
DM42_1084	thyA	DM42_1084	DM42_742	annotation not available	Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	0.633
DM42_3315	DM42_3316	DM42_3315	DM42_3316	annotation not available	ribD C-terminal domain protein	0.549
DM42_3316	DM42_1084	DM42_3316	DM42_1084	ribD C-terminal domain protein	annotation not available	0.558
DM42_3316	DM42_3315	DM42_3316	DM42_3315	ribD C-terminal domain protein	annotation not available	0.549
DM42_3316	DM42_4848	DM42_3316	DM42_4848	ribD C-terminal domain protein	nrdJ_Z- ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent	0.416
DM42_3316	WL94_35110	DM42_3316	DM42_1245	ribD C-terminal domain protein	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	0.416
DM42_3316	dnaN	DM42_3316	DM42_1785	ribD C-terminal domain protein	Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3’-5’ exonuclease proofreading activity. The beta chain is required for initiation of replication as [...]	0.440
DM42_3316	polA	DM42_3316	DM42_4183	ribD C-terminal domain protein	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.720
DM42_3316	ribD	DM42_3316	DM42_881	ribD C-terminal domain protein	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5’-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5’-phosphate; In the C-terminal section; belongs to the HTP reductase family	0.594
DM42_3316	thyA	DM42_3316	DM42_742	ribD C-terminal domain protein	Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	0.663
DM42_3316	ung	DM42_3316	DM42_1314	ribD C-terminal domain protein	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	0.457
DM42_4848	DM42_3316	DM42_4848	DM42_3316	nrdJ_Z- ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent	ribD C-terminal domain protein	0.416
DM42_4848	WL94_35110	DM42_4848	DM42_1245	nrdJ_Z- ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	0.800
DM42_4848	dnaN	DM42_4848	DM42_1785	nrdJ_Z- ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent	Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3’-5’ exonuclease proofreading activity. The beta chain is required for initiation of replication as [...]	0.794
DM42_4848	polA	DM42_4848	DM42_4183	nrdJ_Z- ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.819
DM42_4848	thyA	DM42_4848	DM42_742	nrdJ_Z- ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent	Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	0.828
DM42_4848	ung	DM42_4848	DM42_1314	nrdJ_Z- ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	0.442

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