node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DM42_1084 | DM42_3316 | DM42_1084 | DM42_3316 | annotation not available | ribD C-terminal domain protein | 0.558 |
DM42_1084 | polA | DM42_1084 | DM42_4183 | annotation not available | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.804 |
DM42_1084 | ribD | DM42_1084 | DM42_881 | annotation not available | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate; In the C-terminal section; belongs to the HTP reductase family | 0.803 |
DM42_1084 | thyA | DM42_1084 | DM42_742 | annotation not available | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.633 |
DM42_3315 | DM42_3316 | DM42_3315 | DM42_3316 | annotation not available | ribD C-terminal domain protein | 0.549 |
DM42_3316 | DM42_1084 | DM42_3316 | DM42_1084 | ribD C-terminal domain protein | annotation not available | 0.558 |
DM42_3316 | DM42_3315 | DM42_3316 | DM42_3315 | ribD C-terminal domain protein | annotation not available | 0.549 |
DM42_3316 | DM42_4848 | DM42_3316 | DM42_4848 | ribD C-terminal domain protein | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | 0.416 |
DM42_3316 | WL94_35110 | DM42_3316 | DM42_1245 | ribD C-terminal domain protein | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | 0.416 |
DM42_3316 | dnaN | DM42_3316 | DM42_1785 | ribD C-terminal domain protein | Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as [...] | 0.440 |
DM42_3316 | polA | DM42_3316 | DM42_4183 | ribD C-terminal domain protein | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.720 |
DM42_3316 | ribD | DM42_3316 | DM42_881 | ribD C-terminal domain protein | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate; In the C-terminal section; belongs to the HTP reductase family | 0.594 |
DM42_3316 | thyA | DM42_3316 | DM42_742 | ribD C-terminal domain protein | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.663 |
DM42_3316 | ung | DM42_3316 | DM42_1314 | ribD C-terminal domain protein | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine | 0.457 |
DM42_4848 | DM42_3316 | DM42_4848 | DM42_3316 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | ribD C-terminal domain protein | 0.416 |
DM42_4848 | WL94_35110 | DM42_4848 | DM42_1245 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides | 0.800 |
DM42_4848 | dnaN | DM42_4848 | DM42_1785 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as [...] | 0.794 |
DM42_4848 | polA | DM42_4848 | DM42_4183 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity | 0.819 |
DM42_4848 | thyA | DM42_4848 | DM42_742 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis | 0.828 |
DM42_4848 | ung | DM42_4848 | DM42_1314 | nrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine | 0.442 |