Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WL94_12255
annotation not available (263 aa)
Predicted Functional Partners:
WI67_23530
Preprotein translocase subunit SecD
0.705
DM42_3712
annotation not available
0.536
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
DM42_3712
WI67_23530
DM42_3712
DM42_3713
annotation not available
Preprotein translocase subunit SecD
0.755
DM42_3712
WL94_12255
DM42_3712
DM42_3714
annotation not available
annotation not available
0.536
WI67_23530
DM42_3712
DM42_3713
DM42_3712
Preprotein translocase subunit SecD
annotation not available
0.755
WI67_23530
WL94_12255
DM42_3713
DM42_3714
Preprotein translocase subunit SecD
annotation not available
0.705
WL94_12255
DM42_3712
DM42_3714
DM42_3712
annotation not available
annotation not available
0.536
WL94_12255
WI67_23530
DM42_3714
DM42_3713
annotation not available
Preprotein translocase subunit SecD
0.705
WL94_12255
rpoA
DM42_3714
DM42_1447
annotation not available
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
0.415
rpoA
WL94_12255
DM42_1447
DM42_3714
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
annotation not available
0.415
Network Stats
Network Stats analysis is still ongoing, please wait ...
Functional enrichments in your networkNote: some enrichments may be expected here (why?) explain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: