The upcoming version of STRING is available for preview: it includes new data, new enrichment categories (e.g. diseases and tissues) and covers 14000 fully sequenced genomes.
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DM42_387
Conserved hypothetical protein (362 aa)
Predicted Functional Partners:
WL94_13005
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
DM42_384
DM42_386
DM42_384
DM42_386
Conserved hypothetical protein
annotation not available
0.439
DM42_384
DM42_387
DM42_384
DM42_387
Conserved hypothetical protein
Conserved hypothetical protein
0.456
DM42_386
DM42_384
DM42_386
DM42_384
annotation not available
Conserved hypothetical protein
0.439
DM42_386
DM42_387
DM42_386
DM42_387
annotation not available
Conserved hypothetical protein
0.602
DM42_386
WL94_13005
DM42_386
DM42_388
annotation not available
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
0.488
DM42_387
DM42_384
DM42_387
DM42_384
Conserved hypothetical protein
Conserved hypothetical protein
0.456
DM42_387
DM42_386
DM42_387
DM42_386
Conserved hypothetical protein
annotation not available
0.602
DM42_387
WL94_13005
DM42_387
DM42_388
Conserved hypothetical protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
0.679
WL94_13005
DM42_386
DM42_388
DM42_386
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
annotation not available
0.488
WL94_13005
DM42_387
DM42_388
DM42_387
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
Conserved hypothetical protein
0.679
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) explain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed:
STRING Data Update
