STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhASuccinate dehydrogenase / fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily (591 aa)    
Predicted Functional Partners:
sdhB
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family
 
 0.999
sdhC
Succinate dehydrogenase / fumarate reductase, cytochrome b subunit; succ_dehyd_cytB: succinate dehydrogenase, cytochrome b556 subunit
 
 0.999
DM42_7075
dhsB: succinate dehydrogenase and fumarate reductase iron-sulfur family protein
 
 0.999
sdhD
Succinate dehydrogenase / fumarate reductase, membrane anchor subunit; Succ_dehyd_anc: succinate dehydrogenase, hydrophobic membrane anchor protein
 
 0.998
sucC
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
 
 0.989
fumC
Fumarate hydratase, class ii; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
  
 0.988
fumA
Hydrolyase, tartrate alpha subunit/fumarate, fe-s type domain protein; Catalyzes the reversible hydration of fumarate to (S)-malate
  
 
 0.980
sucD
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
 
 0.976
cyoB
Cytochrome o ubiquinol oxidase subunit i; Belongs to the heme-copper respiratory oxidase family
   
 0.942
cyoC
cyoC: cytochrome o ubiquinol oxidase, subunit III
   
 
 0.937
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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