node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DM42_1084 | WI67_05240 | DM42_1084 | DM42_745 | annotation not available | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | 0.558 |
DM42_1084 | WL94_30540 | DM42_1084 | DM42_2030 | annotation not available | Diguanylate cyclase; folB_dom: FolB domain protein | 0.472 |
DM42_1084 | folC | DM42_1084 | DM42_4091 | annotation not available | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; folC: bifunctional FolC family protein; Belongs to the folylpolyglutamate synthase family | 0.718 |
DM42_1084 | folK | DM42_1084 | DM42_1081 | annotation not available | folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | 0.662 |
DM42_1084 | folP | DM42_1084 | DM42_423 | annotation not available | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives | 0.983 |
DM42_1084 | ribD | DM42_1084 | DM42_881 | annotation not available | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate; In the C-terminal section; belongs to the HTP reductase family | 0.803 |
DM42_882 | WI67_21175 | DM42_882 | DM42_4257 | ribE: riboflavin synthase, alpha subunit | ribE: riboflavin synthase, alpha subunit | 0.834 |
DM42_882 | folK | DM42_882 | DM42_1081 | ribE: riboflavin synthase, alpha subunit | folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | 0.426 |
DM42_882 | folP | DM42_882 | DM42_423 | ribE: riboflavin synthase, alpha subunit | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives | 0.797 |
DM42_882 | ribD | DM42_882 | DM42_881 | ribE: riboflavin synthase, alpha subunit | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate; In the C-terminal section; belongs to the HTP reductase family | 0.997 |
WI67_05240 | DM42_1084 | DM42_745 | DM42_1084 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | annotation not available | 0.558 |
WI67_05240 | folC | DM42_745 | DM42_4091 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; folC: bifunctional FolC family protein; Belongs to the folylpolyglutamate synthase family | 0.965 |
WI67_05240 | folK | DM42_745 | DM42_1081 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | 0.417 |
WI67_05240 | folP | DM42_745 | DM42_423 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives | 0.836 |
WI67_05240 | ribD | DM42_745 | DM42_881 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate; In the C-terminal section; belongs to the HTP reductase family | 0.594 |
WI67_21175 | DM42_882 | DM42_4257 | DM42_882 | ribE: riboflavin synthase, alpha subunit | ribE: riboflavin synthase, alpha subunit | 0.834 |
WI67_21175 | folP | DM42_4257 | DM42_423 | ribE: riboflavin synthase, alpha subunit | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives | 0.787 |
WI67_21175 | ribD | DM42_4257 | DM42_881 | ribE: riboflavin synthase, alpha subunit | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate; In the C-terminal section; belongs to the HTP reductase family | 0.961 |
WL94_25240 | WL94_30540 | DM42_5601 | DM42_2030 | annotation not available | Diguanylate cyclase; folB_dom: FolB domain protein | 0.900 |
WL94_25240 | folK | DM42_5601 | DM42_1081 | annotation not available | folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | 0.941 |