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WL94_14395 protein (Burkholderia cepacia) - STRING interaction network
"WL94_14395" - Cysteine desulfurase IscS in Burkholderia cepacia
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Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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WL94_14395Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily (403 aa)    
Predicted Functional Partners:
iscU
Iron-sulfur cluster assembly scaffold protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (135 aa)
 
 
  0.985
hscB
Co-chaperone protein HscB homolog; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (175 aa)
 
 
  0.907
iscR
iscR- iron-sulfur cluster assembly transcription factor IscR (179 aa)
   
  0.879
WI67_11485
Fdx_isc- ferredoxin, 2Fe-2S type, ISC system (113 aa)
 
 
  0.863
DM42_4598
Fdx_isc- ferredoxin, 2Fe-2S type, ISC system (112 aa)
 
 
  0.861
WI67_21565
annotation not available (289 aa)
   
  0.845
WL94_13745
annotation not available (250 aa)
   
  0.839
WL94_01515
annotation not available (492 aa)
    
   
 
0.813
WI67_11510
Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily (407 aa)
    
   
 
0.802
hscA
Chaperone protein HscA homolog; Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB (612 aa)
 
   
  0.711
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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