STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
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[Homology]
Score
DM42_4667Arac family transcriptional regulator, regulatory protein of adaptative response / dna-3-methyladenine glycosylase ii; alkA N-terminal domain protein (483 aa)    
Predicted Functional Partners:
DM42_4668
Ogt: methylated-DNA-[]-cysteine S-methyltransferase family protein
 
 0.980
DM42_1804
DNA-3-methyladenine glycosylase II; 3-methyladenine DNA glycosylase 2; alkA N-terminal domain protein
 
 
0.851
polA
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
  
 
 0.839
alkA_2
annotation not available
  
 
 0.829
nth
Endonuclease iii; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate
  
 
 0.741
DM42_2295
3mg: DNA-3-methyladenine glycosylase family protein
  
  
 0.701
DM42_827
Dnaq: exonuclease, DNA polymerase III, epsilon subunit family domain protein
  
  
 0.699
mutY
A/g-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs
  
  
 0.694
recA
Recombination protein reca; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
   
 
 0.673
lexA
Repressor lexa; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
    
 
 0.673
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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