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prpB protein (Burkholderia cepacia) - STRING interaction network
"prpB" - 2-methylisocitrate lyase in Burkholderia cepacia
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate; Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family (297 aa)    
Predicted Functional Partners:
WL94_00340
cit_synth_II- 2-methylcitrate synthase/citrate synthase II family protein; Belongs to the citrate synthase family (390 aa)
   
  0.976
acnB
acnB- aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family (861 aa)
         
  0.954
prpD
prpD- 2-methylcitrate dehydratase (483 aa)
 
   
  0.908
aceB
malate_syn_A- malate synthase A; Belongs to the malate synthase family (530 aa)
   
 
  0.905
prpF
3-methylitaconate isomerase; prpF- putative AcnD-accessory protein PrpF (396 aa)
 
   
  0.903
sucC
Succinate--CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (388 aa)
         
  0.903
sucD
Succinate--CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit (293 aa)
         
  0.903
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily (724 aa)
     
 
  0.889
acnD
2met_isocit_dHY- 2-methylisocitrate dehydratase, Fe/S-dependent (864 aa)
 
 
  0.870
WL94_08125
annotation not available (555 aa)
   
 
  0.864
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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