nhaA protein (Burkholderia cepacia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

nhaA

nhaA- Na+/H+ antiporter NhaA (592 aa)

Predicted Functional Partners:

WL94_14115

0.794

secY

0.763

DM42_7351

0.699

clpP

0.664

DM42_657

0.659

polA

0.649

WL94_15690

0.625

dsbB

0.624

ackA

0.605

trmE

0.593

Your Current Organism:

Burkholderia cepacia

NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia, Burkholderia cepacia genomovar I, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DM42_657	clpP	DM42_657	DM42_3175	Uvra- excinuclease ABC subunit A	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family	0.453
DM42_657	nhaA	DM42_657	DM42_658	Uvra- excinuclease ABC subunit A	nhaA- Na+/H+ antiporter NhaA	0.659
DM42_657	polA	DM42_657	DM42_4183	Uvra- excinuclease ABC subunit A	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.780
DM42_7351	WL94_15690	DM42_7351	DM42_1444	annotation not available	annotation not available	0.877
DM42_7351	dsbB	DM42_7351	DM42_808	annotation not available	Disulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity). Required for the production of extracellular protease	0.629
DM42_7351	nhaA	DM42_7351	DM42_658	annotation not available	nhaA- Na+/H+ antiporter NhaA	0.699
WL94_14115	nhaA	DM42_2285	DM42_658	annotation not available	nhaA- Na+/H+ antiporter NhaA	0.794
WL94_14115	polA	DM42_2285	DM42_4183	annotation not available	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.578
WL94_14115	trmE	DM42_2285	DM42_1792	annotation not available	tRNA modification GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. TrmE GTPase family	0.447
WL94_15690	DM42_7351	DM42_1444	DM42_7351	annotation not available	annotation not available	0.877
WL94_15690	dsbB	DM42_1444	DM42_808	annotation not available	Disulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity). Required for the production of extracellular protease	0.547
WL94_15690	nhaA	DM42_1444	DM42_658	annotation not available	nhaA- Na+/H+ antiporter NhaA	0.625
ackA	clpP	DM42_4870	DM42_3175	ackA- acetate kinase	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family	0.531
ackA	nhaA	DM42_4870	DM42_658	ackA- acetate kinase	nhaA- Na+/H+ antiporter NhaA	0.605
ackA	polA	DM42_4870	DM42_4183	ackA- acetate kinase	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.695
clpP	DM42_657	DM42_3175	DM42_657	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family	Uvra- excinuclease ABC subunit A	0.453
clpP	ackA	DM42_3175	DM42_4870	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family	ackA- acetate kinase	0.531
clpP	nhaA	DM42_3175	DM42_658	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family	nhaA- Na+/H+ antiporter NhaA	0.664
clpP	polA	DM42_3175	DM42_4183	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity	0.717
clpP	secY	DM42_3175	DM42_1453	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins; Belongs to the peptidase S14 family	Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	0.546

page 1 of 3

Network

Neighborhood

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Fusion

© STRING Consortium 2019

Credits

Access

Info

About