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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uca
Urea_carbox: urea carboxylase (1206 aa)
Predicted Functional Partners:
WL94_22715
UPF0271 protein WL94_22715; Belongs to the UPF0271 (lamB) family
0.999
WI67_15660
annotation not available
0.999
atzF
Allophanate_hyd: allophanate hydrolase
0.999
WL94_19245
Urea carboxylase
0.979
WL94_19240
Urea carboxylase
0.979
ureA
Urease_gam: urease, gamma subunit; Belongs to the urease gamma subunit family
0.960
ureB
Urease_beta: urease, beta subunit; Belongs to the urease beta subunit family
0.959
ureC
Urease_alph: urease, alpha subunit; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family
0.958
WL94_30320
annotation not available
0.953
accB
Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA