node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABF63906.1 | ABF64433.1 | TM1040_1173 | TM1040_1700 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.912 |
ABF63906.1 | ABF65125.1 | TM1040_1173 | TM1040_2393 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Glycine cleavage system T protein. | 0.924 |
ABF63906.1 | fhs | TM1040_1173 | TM1040_2358 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.922 |
ABF63906.1 | fmt | TM1040_1173 | TM1040_2577 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.913 |
ABF63906.1 | folD | TM1040_1173 | TM1040_2356 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
ABF63906.1 | glyA | TM1040_1173 | TM1040_1579 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
ABF63906.1 | purH | TM1040_1173 | TM1040_0091 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.920 |
ABF63906.1 | purN | TM1040_1173 | TM1040_1475 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase. | 0.914 |
ABF63906.1 | thyA | TM1040_1173 | TM1040_1729 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.910 |
ABF64433.1 | ABF63906.1 | TM1040_1700 | TM1040_1173 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.912 |
ABF64433.1 | ABF65125.1 | TM1040_1700 | TM1040_2393 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein. | 0.912 |
ABF64433.1 | fhs | TM1040_1700 | TM1040_2358 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.440 |
ABF64433.1 | folD | TM1040_1700 | TM1040_2356 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.949 |
ABF64433.1 | glyA | TM1040_1700 | TM1040_1579 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
ABF64433.1 | thyA | TM1040_1700 | TM1040_1729 | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.915 |
ABF64636.1 | folD | TM1040_1903 | TM1040_2356 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.941 |
ABF64636.1 | purN | TM1040_1903 | TM1040_1475 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase. | 0.928 |
ABF65125.1 | ABF63906.1 | TM1040_2393 | TM1040_1173 | Glycine cleavage system T protein. | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.924 |
ABF65125.1 | ABF64433.1 | TM1040_2393 | TM1040_1700 | Glycine cleavage system T protein. | 510-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.912 |
ABF65125.1 | fhs | TM1040_2393 | TM1040_2358 | Glycine cleavage system T protein. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.922 |