STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folE2Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (269 aa)    
Predicted Functional Partners:
Tbd_2314
6-pyruvoyl tetrahydrobiopterin synthase.
 
  
 0.933
Tbd_2184
6-pyruvoyl tetrahydrobiopterin synthase.
    
 0.919
folE
GTP cyclohydrolase I.
     
 0.913
Tbd_0481
GTP cyclohydrolase I; Belongs to the GTP cyclohydrolase I family.
     
 0.913
ribB
3,4-Dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
     
 0.911
Tbd_0444
NUDIX hydrolase; Belongs to the Nudix hydrolase family.
     
  0.900
moaA
Elongator protein 3/MiaB/NifB; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
     
  0.900
Tbd_2051
7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK.
   
 0.824
pykA
Pyruvate kinase; Belongs to the pyruvate kinase family.
    
  0.822
Tbd_0471
Metal dependent phosphohydrolase, HD region; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
  0.800
Your Current Organism:
Thiobacillus denitrificans ATCC 25259
NCBI taxonomy Id: 292415
Other names: T. denitrificans ATCC 25259, Thiobacillus denitrificans str. ATCC 25259, Thiobacillus denitrificans strain ATCC 25259
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