node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tbd_1237 | Tbd_1431 | Tbd_1237 | Tbd_1431 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Putative heat shock protein, DnaJ family. | 0.741 |
Tbd_1237 | Tbd_1999 | Tbd_1237 | Tbd_1999 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein DnaJ. | 0.741 |
Tbd_1237 | dnaJ | Tbd_1237 | Tbd_1539 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 0.771 |
Tbd_1237 | dnaK | Tbd_1237 | Tbd_1538 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.940 |
Tbd_1237 | groL | Tbd_1237 | Tbd_0091 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin GroEL (Hsp60, Cpn10); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.654 |
Tbd_1237 | groS | Tbd_1237 | Tbd_0092 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin GroES (Hsp10, Cpn10)); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.720 |
Tbd_1237 | grpE | Tbd_1237 | Tbd_1537 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several round [...] | 0.895 |
Tbd_1237 | htpG | Tbd_1237 | Tbd_1078 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein htpG; Molecular chaperone. Has ATPase activity. | 0.802 |
Tbd_1431 | Tbd_1237 | Tbd_1431 | Tbd_1237 | Putative heat shock protein, DnaJ family. | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.741 |
Tbd_1431 | Tbd_1999 | Tbd_1431 | Tbd_1999 | Putative heat shock protein, DnaJ family. | Heat shock protein DnaJ. | 0.407 |
Tbd_1431 | clpB | Tbd_1431 | Tbd_0815 | Putative heat shock protein, DnaJ family. | ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.741 |
Tbd_1431 | dnaK | Tbd_1431 | Tbd_1538 | Putative heat shock protein, DnaJ family. | Molecular chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.973 |
Tbd_1431 | groL | Tbd_1431 | Tbd_0091 | Putative heat shock protein, DnaJ family. | Chaperonin GroEL (Hsp60, Cpn10); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.771 |
Tbd_1431 | groS | Tbd_1431 | Tbd_0092 | Putative heat shock protein, DnaJ family. | Chaperonin GroES (Hsp10, Cpn10)); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.638 |
Tbd_1431 | grpE | Tbd_1431 | Tbd_1537 | Putative heat shock protein, DnaJ family. | Molecular chaperone protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several round [...] | 0.919 |
Tbd_1431 | htpG | Tbd_1431 | Tbd_1078 | Putative heat shock protein, DnaJ family. | Chaperone protein htpG; Molecular chaperone. Has ATPase activity. | 0.946 |
Tbd_1999 | Tbd_1237 | Tbd_1999 | Tbd_1237 | Heat shock protein DnaJ. | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.741 |
Tbd_1999 | Tbd_1431 | Tbd_1999 | Tbd_1431 | Heat shock protein DnaJ. | Putative heat shock protein, DnaJ family. | 0.407 |
Tbd_1999 | clpB | Tbd_1999 | Tbd_0815 | Heat shock protein DnaJ. | ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.775 |
Tbd_1999 | dnaK | Tbd_1999 | Tbd_1538 | Heat shock protein DnaJ. | Molecular chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.966 |