node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tbd_0234 | Tbd_0843 | Tbd_0234 | Tbd_0843 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.937 |
Tbd_0234 | Tbd_2517 | Tbd_0234 | Tbd_2517 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase (FADH); Belongs to the methylenetetrahydrofolate reductase family. | 0.997 |
Tbd_0234 | ahcY | Tbd_0234 | Tbd_2519 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.952 |
Tbd_0234 | ilvA | Tbd_0234 | Tbd_2363 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Threonine dehydratase I; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.902 |
Tbd_0234 | metAS | Tbd_0234 | Tbd_0246 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. In vitro, can also use glutaryl-CoA as acyl donor; Belongs to the MetA family. | 0.890 |
Tbd_0234 | metE | Tbd_0234 | Tbd_2286 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.984 |
Tbd_0234 | metG | Tbd_0234 | Tbd_0860 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA synthetase, class Ia; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.943 |
Tbd_0234 | metK | Tbd_0234 | Tbd_2521 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.952 |
Tbd_0234 | metZ | Tbd_0234 | Tbd_1907 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.985 |
Tbd_0843 | Tbd_0234 | Tbd_0843 | Tbd_0234 | Homoserine dehydrogenase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.937 |
Tbd_0843 | Tbd_2517 | Tbd_0843 | Tbd_2517 | Homoserine dehydrogenase. | 5,10-methylenetetrahydrofolate reductase (FADH); Belongs to the methylenetetrahydrofolate reductase family. | 0.642 |
Tbd_0843 | ahcY | Tbd_0843 | Tbd_2519 | Homoserine dehydrogenase. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.818 |
Tbd_0843 | ilvA | Tbd_0843 | Tbd_2363 | Homoserine dehydrogenase. | Threonine dehydratase I; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.563 |
Tbd_0843 | metAS | Tbd_0843 | Tbd_0246 | Homoserine dehydrogenase. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. In vitro, can also use glutaryl-CoA as acyl donor; Belongs to the MetA family. | 0.946 |
Tbd_0843 | metE | Tbd_0843 | Tbd_2286 | Homoserine dehydrogenase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.879 |
Tbd_0843 | metG | Tbd_0843 | Tbd_0860 | Homoserine dehydrogenase. | methionyl-tRNA synthetase, class Ia; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.423 |
Tbd_0843 | metZ | Tbd_0843 | Tbd_1907 | Homoserine dehydrogenase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.924 |
Tbd_2285 | metE | Tbd_2285 | Tbd_2286 | Possible Transcriptional Regulator, Fis family; Belongs to the LysR transcriptional regulatory family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.831 |
Tbd_2517 | Tbd_0234 | Tbd_2517 | Tbd_0234 | 5,10-methylenetetrahydrofolate reductase (FADH); Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.997 |
Tbd_2517 | Tbd_0843 | Tbd_2517 | Tbd_0843 | 5,10-methylenetetrahydrofolate reductase (FADH); Belongs to the methylenetetrahydrofolate reductase family. | Homoserine dehydrogenase. | 0.642 |