node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STH2163 | STH414 | STH2163 | STH414 | Branched-chain alpha-keto acid dehydrogenase E3. | Pyruvate dehydrogenase E3; Dihydrolipoamide dehydrogenase. | 0.915 |
STH2163 | fhs | STH2163 | STH3189 | Branched-chain alpha-keto acid dehydrogenase E3. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.449 |
STH2163 | folD | STH2163 | STH1847 | Branched-chain alpha-keto acid dehydrogenase E3. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.453 |
STH2163 | gcvH | STH2163 | STH1921 | Branched-chain alpha-keto acid dehydrogenase E3. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.991 |
STH2163 | gcvPA | STH2163 | STH1920 | Branched-chain alpha-keto acid dehydrogenase E3. | Glycine cleavage system protein P subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.944 |
STH2163 | gcvPB | STH2163 | STH1919 | Branched-chain alpha-keto acid dehydrogenase E3. | Glycine cleavage system protein P subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.944 |
STH2163 | gcvT | STH2163 | STH1922 | Branched-chain alpha-keto acid dehydrogenase E3. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.977 |
STH2163 | glyA | STH2163 | STH1917 | Branched-chain alpha-keto acid dehydrogenase E3. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
STH2500 | fhs | STH2500 | STH3189 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.968 |
STH2500 | folD | STH2500 | STH1847 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.710 |
STH2500 | gcvH | STH2500 | STH1921 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.481 |
STH2500 | gcvPB | STH2500 | STH1919 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Glycine cleavage system protein P subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.490 |
STH2500 | gcvT | STH2500 | STH1922 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.973 |
STH2500 | glyA | STH2500 | STH1917 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
STH2500 | purH | STH2500 | STH2850 | 5-methyltetrahydrofolate S-homocysteine methyltransferase. | Phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase. | 0.918 |
STH414 | STH2163 | STH414 | STH2163 | Pyruvate dehydrogenase E3; Dihydrolipoamide dehydrogenase. | Branched-chain alpha-keto acid dehydrogenase E3. | 0.915 |
STH414 | fhs | STH414 | STH3189 | Pyruvate dehydrogenase E3; Dihydrolipoamide dehydrogenase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.449 |
STH414 | folD | STH414 | STH1847 | Pyruvate dehydrogenase E3; Dihydrolipoamide dehydrogenase. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.453 |
STH414 | gcvH | STH414 | STH1921 | Pyruvate dehydrogenase E3; Dihydrolipoamide dehydrogenase. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.990 |
STH414 | gcvPA | STH414 | STH1920 | Pyruvate dehydrogenase E3; Dihydrolipoamide dehydrogenase. | Glycine cleavage system protein P subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.940 |