node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STH2235 | STH2299 | STH2235 | STH2299 | Pyridoxal phosphate biosynthetic protein variant; Belongs to the PdxA family. | Conserved hypothetical protein. | 0.755 |
STH2235 | STH2300 | STH2235 | STH2300 | Pyridoxal phosphate biosynthetic protein variant; Belongs to the PdxA family. | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | 0.773 |
STH2235 | rsmA | STH2235 | STH3249 | Pyridoxal phosphate biosynthetic protein variant; Belongs to the PdxA family. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.418 |
STH2298 | STH2299 | STH2298 | STH2299 | DeoR-family transcriptional regulator. | Conserved hypothetical protein. | 0.848 |
STH2298 | STH2300 | STH2298 | STH2300 | DeoR-family transcriptional regulator. | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | 0.544 |
STH2298 | STH2301 | STH2298 | STH2301 | DeoR-family transcriptional regulator. | Gluconate permease. | 0.512 |
STH2299 | STH2235 | STH2299 | STH2235 | Conserved hypothetical protein. | Pyridoxal phosphate biosynthetic protein variant; Belongs to the PdxA family. | 0.755 |
STH2299 | STH2298 | STH2299 | STH2298 | Conserved hypothetical protein. | DeoR-family transcriptional regulator. | 0.848 |
STH2299 | STH2300 | STH2299 | STH2300 | Conserved hypothetical protein. | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | 0.929 |
STH2299 | STH2301 | STH2299 | STH2301 | Conserved hypothetical protein. | Gluconate permease. | 0.778 |
STH2300 | STH2235 | STH2300 | STH2235 | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | Pyridoxal phosphate biosynthetic protein variant; Belongs to the PdxA family. | 0.773 |
STH2300 | STH2298 | STH2300 | STH2298 | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | DeoR-family transcriptional regulator. | 0.544 |
STH2300 | STH2299 | STH2300 | STH2299 | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | Conserved hypothetical protein. | 0.929 |
STH2300 | STH2301 | STH2300 | STH2301 | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | Gluconate permease. | 0.688 |
STH2300 | STH3116 | STH2300 | STH3116 | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.689 |
STH2300 | dapA | STH2300 | STH1549 | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.632 |
STH2300 | gyrB | STH2300 | STH6 | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | DNA gyrase B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.813 |
STH2300 | rsmA | STH2300 | STH3249 | Pyridoxine phosphate biosynthetic protein; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP); Belongs to the PdxA family. PdxA2 subfamily. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.668 |
STH2301 | STH2298 | STH2301 | STH2298 | Gluconate permease. | DeoR-family transcriptional regulator. | 0.512 |
STH2301 | STH2299 | STH2301 | STH2299 | Gluconate permease. | Conserved hypothetical protein. | 0.778 |