STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AFZ48454.1Catalytic domain-containing protein of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078:IPR003016; KEGG: syp:SYNPCC7002_A0110 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: catalytic domain-containing protein of components of various [...] (420 aa)    
Predicted Functional Partners:
pdhA
Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.999
AFZ48196.1
Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.999
AFZ48207.1
Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR012999:IPR013027:IPR004099:IPR006258:IPR 000815; KEGG: cyp:PCC8801_3920 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrol [...]
 0.999
AFZ46233.1
PFAM: ATP-grasp domain; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR011761:IPR013650; KEGG: cyh:Cyan8802_0543 ATP-grasp domain protein; PFAM: ATP-grasp domain protein; SPTR: ATP-grasp domain protein.
  
 0.982
AFZ48299.1
PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR018062:IPR012999:IPR013027:IPR004099:IPR 000815; KEGG: mar:MAE_22610 mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Mercuric reductase.
 0.982
AFZ46459.1
PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterPro IPR002020:IPR019810:IPR011278; KEGG: cyh:Cyan8802_1408 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; SPTR: 2-methylcitrate synthase/citrate synthase II; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.
  
 0.979
AFZ48481.1
PFAM: Pyridine nucleotide-disulphide oxidoreductase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR001327:IPR013027; KEGG: cyc:PCC7424_0723 pyridine nucleotide-disulphide oxidoreductase dimerisation region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Pyridine nucleotide-disulphide oxidoreductase dimerisation region.
 
 0.973
AFZ48069.1
PFAM: CoA binding domain; COGs: COG0074 Succinyl-CoA synthetase alpha subunit; InterPro IPR003781:IPR018087; KEGG: syn:sll1557 succinyl-CoA synthetase; PFAM: CoA-binding domain protein; SPTR: CoA-binding domain protein.
  
 0.970
AFZ46871.1
PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR018211:IPR015590:IPR001670:IPR012079; KEGG: mar:MAE_49340 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; SPTR: Alcohol dehydrogenase, iron-containing family; alcohol dehydrogenase AdhE; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 0.945
AFZ48684.1
Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 0.930
Your Current Organism:
Cyanobacterium stanieri
NCBI taxonomy Id: 292563
Other names: C. stanieri PCC 7202, Cyanobacterium stanieri PCC 7202, Synechococcus cedrorum CCAP 14792a (no longer available), Synechococcus cedrorum CCAP 14792b (no longer available), Synechococcus cedrorum M137/1a, Synechococcus cedrorum SAG 88.79, Synechococcus sp. ATCC 29140, Synechococcus sp. PCC 7202
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