STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hscBCo-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (166 aa)    
Predicted Functional Partners:
A1C_03955
Scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 
 0.998
A1C_01470
COG0633 Ferredoxin.
 
  
 0.982
A1C_03950
Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family.
 
 
 0.982
hscA
Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
  
 
 0.979
A1C_03970
Iron-sulfur cluster assembly transcription factor IscR; COG1959 Predicted transcriptional regulator.
  
  
 0.914
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.900
A1C_00495
Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family.
  
 
 0.889
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
 
 0.830
A1C_03965
Hypothetical protein; COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
  
 
 0.822
A1C_05740
Glutaredoxin-like protein grla; COG0278 Glutaredoxin-related protein; Belongs to the glutaredoxin family. Monothiol subfamily.
     
 0.778
Your Current Organism:
Rickettsia akari
NCBI taxonomy Id: 293614
Other names: R. akari str. Hartford, Rickettsia akari str. Hartford, Rickettsia akari strain Hartford
Server load: high (88%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.