STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Amet_0173Sporulation stage II, protein E; KEGG: cth:Cthe_2681 serine phosphatase; TIGRFAM: Sporulation stage II, protein E; PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein. (800 aa)    
Predicted Functional Partners:
Amet_2872
Peptidase U4, sporulation factor SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
  
  
 0.962
Amet_4592
TIGRFAM: Sporulation stage II, protein R; KEGG: cth:Cthe_1920 stage II sporulation protein R.
  
   
 0.907
spoIIAB
Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.906
Amet_3054
PFAM: Stage II sporulation P family protein; KEGG: tte:TTE0947 stage II sporulation protein P.
  
   
 0.905
Amet_2513
Response regulator receiver protein; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
  
 0.883
Amet_2870
RNA polymerase, sigma 28 subunit, FliA/WhiG family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.870
Amet_0364
TIGRFAM: Sporulation stage III, transcriptional regulator SpoIIID; KEGG: cno:NT01CX_0524 stage III sporulation protein D.
  
   
 0.869
Amet_2492
TIGRFAM: Sporulation stage III, protein AA; SMART: AAA ATPase; KEGG: cth:Cthe_0845 stage III sporulation protein spoIIIAA.
  
   
 0.851
Amet_0169
PFAM: YabP family protein; KEGG: tte:TTE2450 hypothetical protein.
 
     0.842
Amet_2854
Sporulation stage IV, protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.838
Your Current Organism:
Alkaliphilus metalliredigens
NCBI taxonomy Id: 293826
Other names: A. metalliredigens QYMF, Alkaliphilus metalliredigens QYMF, Alkaliphilus metalliredigens str. QYMF, Alkaliphilus metalliredigens strain QYMF
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