node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amet_0002 | dut | Amet_0002 | Amet_0869 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.901 |
Amet_0340 | Amet_0542 | Amet_0340 | Amet_0542 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding. | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bld:BLi00814 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; RBL02320; Belongs to the 5'-nucleotidase family. | 0.904 |
Amet_0340 | Amet_3610 | Amet_0340 | Amet_3610 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding. | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bcl:ABC0966 nucleotidase; Belongs to the 5'-nucleotidase family. | 0.905 |
Amet_0340 | dut | Amet_0340 | Amet_0869 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.959 |
Amet_0340 | surE | Amet_0340 | Amet_2636 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Amet_0340 | tdk | Amet_0340 | Amet_0325 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding. | PFAM: thymidine kinase; KEGG: tte:TTE0140 Thymidine kinase. | 0.936 |
Amet_0340 | thyX | Amet_0340 | Amet_4498 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.929 |
Amet_0340 | tmk | Amet_0340 | Amet_0082 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.927 |
Amet_0542 | Amet_0340 | Amet_0542 | Amet_0340 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bld:BLi00814 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; RBL02320; Belongs to the 5'-nucleotidase family. | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding. | 0.904 |
Amet_0542 | Amet_3610 | Amet_0542 | Amet_3610 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bld:BLi00814 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; RBL02320; Belongs to the 5'-nucleotidase family. | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bcl:ABC0966 nucleotidase; Belongs to the 5'-nucleotidase family. | 0.939 |
Amet_0542 | dut | Amet_0542 | Amet_0869 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bld:BLi00814 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; RBL02320; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.922 |
Amet_0542 | surE | Amet_0542 | Amet_2636 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bld:BLi00814 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; RBL02320; Belongs to the 5'-nucleotidase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.908 |
Amet_0542 | tdk | Amet_0542 | Amet_0325 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bld:BLi00814 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; RBL02320; Belongs to the 5'-nucleotidase family. | PFAM: thymidine kinase; KEGG: tte:TTE0140 Thymidine kinase. | 0.904 |
Amet_0542 | thyX | Amet_0542 | Amet_4498 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bld:BLi00814 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; RBL02320; Belongs to the 5'-nucleotidase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.900 |
Amet_0542 | tmk | Amet_0542 | Amet_0082 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bld:BLi00814 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; RBL02320; Belongs to the 5'-nucleotidase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.912 |
Amet_1387 | dut | Amet_1387 | Amet_0869 | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; KEGG: tte:TTE1850 oxygen-sensitive ribonucleoside-triphosphate reductase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.954 |
Amet_2788 | dut | Amet_2788 | Amet_0869 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.931 |
Amet_3610 | Amet_0340 | Amet_3610 | Amet_0340 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bcl:ABC0966 nucleotidase; Belongs to the 5'-nucleotidase family. | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cth:Cthe_2599 CMP/dCMP deaminase, zinc-binding. | 0.905 |
Amet_3610 | Amet_0542 | Amet_3610 | Amet_0542 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bcl:ABC0966 nucleotidase; Belongs to the 5'-nucleotidase family. | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bld:BLi00814 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; RBL02320; Belongs to the 5'-nucleotidase family. | 0.939 |
Amet_3610 | dut | Amet_3610 | Amet_0869 | 5'-Nucleotidase domain protein; PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: bcl:ABC0966 nucleotidase; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.907 |