node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amet_2019 | Amet_2022 | Amet_2019 | Amet_2022 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 methenyltetrahydrofolate cyclohydrolase. | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.626 |
Amet_2019 | Amet_4589 | Amet_2019 | Amet_4589 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 methenyltetrahydrofolate cyclohydrolase. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tde:TDE0046 formiminotransferase-cyclodeaminase family protein. | 0.913 |
Amet_2019 | fhs | Amet_2019 | Amet_2018 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 methenyltetrahydrofolate cyclohydrolase. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: dsy:DSY0605 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.982 |
Amet_2019 | fhs-2 | Amet_2019 | Amet_4585 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 methenyltetrahydrofolate cyclohydrolase. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mta:Moth_0109 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.941 |
Amet_2019 | fmt | Amet_2019 | Amet_2785 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 methenyltetrahydrofolate cyclohydrolase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.911 |
Amet_2019 | folD | Amet_2019 | Amet_2020 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 methenyltetrahydrofolate cyclohydrolase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.977 |
Amet_2019 | purN | Amet_2019 | Amet_0924 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 methenyltetrahydrofolate cyclohydrolase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.907 |
Amet_2022 | Amet_2019 | Amet_2022 | Amet_2019 | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 methenyltetrahydrofolate cyclohydrolase. | 0.626 |
Amet_2022 | Amet_3116 | Amet_2022 | Amet_3116 | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: glycine hydroxymethyltransferase; aminotransferase, class I and II; KEGG: pho:PH1654 serine hydroxymethyltransferase. | 0.931 |
Amet_2022 | Amet_3375 | Amet_2022 | Amet_3375 | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: methylenetetrahydrofolate reductase; KEGG: cth:Cthe_0099 5,10-methylenetetrahydrofolate reductase. | 0.900 |
Amet_2022 | Amet_4589 | Amet_2022 | Amet_4589 | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: tde:TDE0046 formiminotransferase-cyclodeaminase family protein. | 0.461 |
Amet_2022 | fhs | Amet_2022 | Amet_2018 | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: dsy:DSY0605 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.901 |
Amet_2022 | fhs-2 | Amet_2022 | Amet_4585 | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mta:Moth_0109 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.862 |
Amet_2022 | folD | Amet_2022 | Amet_2020 | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |
Amet_2022 | glyA | Amet_2022 | Amet_2365 | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.931 |
Amet_3116 | Amet_2022 | Amet_3116 | Amet_2022 | PFAM: glycine hydroxymethyltransferase; aminotransferase, class I and II; KEGG: pho:PH1654 serine hydroxymethyltransferase. | PFAM: methylenetetrahydrofolate reductase; KEGG: mbu:Mbur_1847 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.931 |
Amet_3116 | Amet_3375 | Amet_3116 | Amet_3375 | PFAM: glycine hydroxymethyltransferase; aminotransferase, class I and II; KEGG: pho:PH1654 serine hydroxymethyltransferase. | PFAM: methylenetetrahydrofolate reductase; KEGG: cth:Cthe_0099 5,10-methylenetetrahydrofolate reductase. | 0.931 |
Amet_3116 | fhs | Amet_3116 | Amet_2018 | PFAM: glycine hydroxymethyltransferase; aminotransferase, class I and II; KEGG: pho:PH1654 serine hydroxymethyltransferase. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: dsy:DSY0605 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.962 |
Amet_3116 | fhs-2 | Amet_3116 | Amet_4585 | PFAM: glycine hydroxymethyltransferase; aminotransferase, class I and II; KEGG: pho:PH1654 serine hydroxymethyltransferase. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mta:Moth_0109 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.962 |
Amet_3116 | fmt | Amet_3116 | Amet_2785 | PFAM: glycine hydroxymethyltransferase; aminotransferase, class I and II; KEGG: pho:PH1654 serine hydroxymethyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.936 |