STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
iscSAminotransferase, class V; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (395 aa)    
Predicted Functional Partners:
Amet_2454
PFAM: nitrogen-fixing NifU domain protein; KEGG: cth:Cthe_0721 nitrogen-fixing NifU-like protein.
 
 0.999
Amet_2452
TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074; KEGG: tte:TTE1242 predicted transcriptional regulator.
  
 0.990
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 
 0.968
Amet_0055
PFAM: SirA family protein; KEGG: gme:Gmet_1571 hypothetical protein; Belongs to the sulfur carrier protein TusA family.
   
 0.953
Amet_3547
PFAM: SirA family protein; KEGG: gsu:GSU2521 hypothetical protein; Belongs to the sulfur carrier protein TusA family.
   
 0.953
Amet_0047
PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: sus:Acid_0749 UBA/ThiF-type NAD/FAD binding protein.
   
 0.949
Amet_3501
PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: cth:Cthe_2539 UBA/ThiF-type NAD/FAD binding fold.
   
 0.949
Amet_3290
SMART: Rhodanese domain protein; KEGG: ppr:PBPRA1240 putative thiosulfate sulfur transferase.
  
 0.918
Amet_3291
PFAM: Rhodanese domain protein; KEGG: cpr:CPR_1124 putative thiosulfate sulfurtransferase.
  
 0.918
Amet_3096
Molybdopterin oxidoreductase; PFAM: ferredoxin; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein; molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; KEGG: swo:Swol_0658 glutamate synthase beta chain-related oxidoreductase, containing 2Fe-2S and 4Fe-4S clusters.
  
 0.912
Your Current Organism:
Alkaliphilus metalliredigens
NCBI taxonomy Id: 293826
Other names: A. metalliredigens QYMF, Alkaliphilus metalliredigens QYMF, Alkaliphilus metalliredigens str. QYMF, Alkaliphilus metalliredigens strain QYMF
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