STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
grdAGlycine reductase; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination. (158 aa)    
Predicted Functional Partners:
Amet_3591
Selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; KEGG: chy:CHY_2393 glycine reductase, selenoprotein B; Contains selenocysteine; TIGRFAM: glycine reductase, selenoprotein B; selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; PFAM: Selenoprotein B, glycine/betaine/sarcosine/D-proline reductase.
 
  
 0.981
Amet_3594
PFAM: Thioredoxin domain; KEGG: tte:TTE1880 Thiol-disulfide isomerase and thioredoxins; Belongs to the thioredoxin family.
 
   
 0.978
Amet_3593
PFAM: Glycine/sarcosine/betaine reductase complex, protein B, alpha and beta subunits; KEGG: tte:TTE1879 GrdE proprotein.
 
   
 0.960
Amet_3595
TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; FAD dependent oxidoreductase; KEGG: tte:TTE1881 thioredoxin reductase.
 
   
 0.953
Amet_3590
Betaine reductase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: tte:TTE1875 3-oxoacyl-(acyl-carrier-protein) synthase III.
 
   
 0.918
Amet_3589
Glycine reductase; PFAM: fatty acid synthesis plsX protein; KEGG: tte:TTE1874 fatty acid/phospholipid biosynthesis enzyme.
 
   
 0.915
Amet_3596
KEGG: tte:TTE1882 GrdX protein.
 
   
 0.885
selD
Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP.
      
 0.841
Amet_0667
D-proline reductase (dithiol); KEGG: ade:Adeh_1149 hypothetical protein.
 
   
 0.781
Amet_3548
KEGG: chy:CHY_0235 hypothetical protein.
  
     0.734
Your Current Organism:
Alkaliphilus metalliredigens
NCBI taxonomy Id: 293826
Other names: A. metalliredigens QYMF, Alkaliphilus metalliredigens QYMF, Alkaliphilus metalliredigens str. QYMF, Alkaliphilus metalliredigens strain QYMF
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