STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
S2208Putative imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)    
Predicted Functional Partners:
VV12913
Putative phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the PRA-PH family.
  
 0.999
hisA
Putative phosphoribosylformimino-5-aminoimidazole carboxamideribonucleotide isomerase; Predicted by orpheus program; predicted by glimmer program.
 
0.999
SF2085
Putative glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 0.999
hisB
Putative imidazoleglycerol-phosphatedehydratase/histidinol- phosphatase; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
 
 0.999
VV1351
Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.997
HISG
Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.987
hisC
Putative histidinol-phosphate aminotransferase; Predicted by orpheus program; predicted by glimmer program; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.985
HISC
Putative histidinol phosphate aminotransferase; Predicted by orpheus program; predicted by glimmer program.
 
  
 0.975
Y3738
Putative phosphoserine phosphatase; Predicted by orpheus program; predicted by glimmer program.
  
  
 0.879
YPO1315
Hypothetical hydrolase; Predicted by orpheus program; predicted by glimmer program.
  
  
 0.879
Your Current Organism:
Photobacterium profundum
NCBI taxonomy Id: 298386
Other names: P. profundum SS9, Photobacterium SS9, Photobacterium profundum SS9, Photobacterium profundum str. SS9, Photobacterium profundum strain SS9, Photobacterium sp. (strain SS9), Photobacterium sp. SS9, deep-sea eubacterium SS9
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