node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C0645 | FHS | PBPRA2641 | PBPRA2764 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family. | 0.994 |
C0645 | GLYA | PBPRA2641 | PBPRA0795 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.986 |
C0645 | R01549 | PBPRA2641 | PBPRB1319 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative glycine cleavage system T protein; Predicted by orpheus program; predicted by glimmer program. | 0.964 |
C0645 | S2693 | PBPRA2641 | PBPRA2911 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative phosphoribosylglycinamide formyltransferase 2; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.970 |
C0645 | SF4078 | PBPRA2641 | PBPRA3419 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative osphoribosylaminoimidazolecarboxamideformyltransferase/IMP cyclohydrolase; Predicted by orpheus program; predicted by glimmer program. | 0.978 |
C0645 | STM3061 | PBPRA2641 | PBPRA3121 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Hypothetical 5-formyltetrahydrofolatecyclo-ligase-family protein; Predicted by orpheus program; predicted by glimmer program; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.948 |
C0645 | T3511 | PBPRA2641 | PBPRA0263 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative 5,10-methylenetetrahydrofolate reductase; Predicted by orpheus program; predicted by glimmer program; Belongs to the methylenetetrahydrofolate reductase family. | 0.933 |
C0645 | VV0679 | PBPRA2641 | PBPRA0581 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative thymidylate synthetase (thyA); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.941 |
C0645 | VVA0693 | PBPRA2641 | PBPRB1322 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
C0645 | fmt | PBPRA2641 | PBPRA3580 | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.977 |
FHS | C0645 | PBPRA2764 | PBPRA2641 | Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family. | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
FHS | GLYA | PBPRA2764 | PBPRA0795 | Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family. | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |
FHS | R01549 | PBPRA2764 | PBPRB1319 | Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family. | Putative glycine cleavage system T protein; Predicted by orpheus program; predicted by glimmer program. | 0.947 |
FHS | S2693 | PBPRA2764 | PBPRA2911 | Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family. | Putative phosphoribosylglycinamide formyltransferase 2; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.966 |
FHS | SF4078 | PBPRA2764 | PBPRA3419 | Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family. | Putative osphoribosylaminoimidazolecarboxamideformyltransferase/IMP cyclohydrolase; Predicted by orpheus program; predicted by glimmer program. | 0.990 |
FHS | STM3061 | PBPRA2764 | PBPRA3121 | Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family. | Hypothetical 5-formyltetrahydrofolatecyclo-ligase-family protein; Predicted by orpheus program; predicted by glimmer program; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.423 |
FHS | VVA0693 | PBPRA2764 | PBPRB1322 | Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family. | Putative glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |
GLYA | C0645 | PBPRA0795 | PBPRA2641 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.986 |
GLYA | FHS | PBPRA0795 | PBPRA2764 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family. | 0.964 |
GLYA | R01549 | PBPRA0795 | PBPRB1319 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative glycine cleavage system T protein; Predicted by orpheus program; predicted by glimmer program. | 0.986 |