node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABW10146.1 | ABW13566.1 | Franean1_0687 | Franean1_4182 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: fal:FRAAL6398 putative ligase (partial match); Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rha:RHA1_ro01816 probable methenyltetrahydrofolate cyclohydrolase. | 0.922 |
ABW10146.1 | folD | Franean1_0687 | Franean1_4183 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: fal:FRAAL6398 putative ligase (partial match); Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.926 |
ABW10146.1 | purN | Franean1_0687 | Franean1_5974 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: fal:FRAAL6398 putative ligase (partial match); Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate; Belongs to the GART family. | 0.524 |
ABW13566.1 | ABW10146.1 | Franean1_4182 | Franean1_0687 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rha:RHA1_ro01816 probable methenyltetrahydrofolate cyclohydrolase. | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: fal:FRAAL6398 putative ligase (partial match); Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.922 |
ABW13566.1 | ABW15282.1 | Franean1_4182 | Franean1_5938 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rha:RHA1_ro01816 probable methenyltetrahydrofolate cyclohydrolase. | PFAM: formyl transferase domain protein; KEGG: sco:SCO0499 formyltransferase. | 0.912 |
ABW13566.1 | fmt | Franean1_4182 | Franean1_1719 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rha:RHA1_ro01816 probable methenyltetrahydrofolate cyclohydrolase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
ABW13566.1 | folD | Franean1_4182 | Franean1_4183 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rha:RHA1_ro01816 probable methenyltetrahydrofolate cyclohydrolase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.988 |
ABW13566.1 | gcvT | Franean1_4182 | Franean1_1782 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rha:RHA1_ro01816 probable methenyltetrahydrofolate cyclohydrolase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.933 |
ABW13566.1 | purN | Franean1_4182 | Franean1_5974 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rha:RHA1_ro01816 probable methenyltetrahydrofolate cyclohydrolase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate; Belongs to the GART family. | 0.932 |
ABW14484.1 | fmt | Franean1_5126 | Franean1_1719 | KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.433 |
ABW14484.1 | folD | Franean1_5126 | Franean1_4183 | KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.942 |
ABW14484.1 | gcvT | Franean1_5126 | Franean1_1782 | KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.920 |
ABW14484.1 | glyA | Franean1_5126 | Franean1_1013 | KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
ABW14484.1 | glyA-2 | Franean1_5126 | Franean1_2509 | KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
ABW14484.1 | purN | Franean1_5126 | Franean1_5974 | KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate; Belongs to the GART family. | 0.502 |
ABW14484.1 | thyX | Franean1_5126 | Franean1_1195 | KEGG: fal:FRAAL2163 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.934 |
ABW15282.1 | ABW13566.1 | Franean1_5938 | Franean1_4182 | PFAM: formyl transferase domain protein; KEGG: sco:SCO0499 formyltransferase. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rha:RHA1_ro01816 probable methenyltetrahydrofolate cyclohydrolase. | 0.912 |
ABW15282.1 | fmt | Franean1_5938 | Franean1_1719 | PFAM: formyl transferase domain protein; KEGG: sco:SCO0499 formyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.913 |
ABW15282.1 | folD | Franean1_5938 | Franean1_4183 | PFAM: formyl transferase domain protein; KEGG: sco:SCO0499 formyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.952 |
ABW15282.1 | gcvT | Franean1_5938 | Franean1_1782 | PFAM: formyl transferase domain protein; KEGG: sco:SCO0499 formyltransferase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.938 |