STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prcA20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. (239 aa)    
Predicted Functional Partners:
prcB
20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.
 
 0.999
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
 
 0.999
ABW09753.1
KEGG: fal:FRAAL6599 hypothetical protein.
  
 
 
 0.990
pup
Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
 
 
 
 0.984
pafA
Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.
   
 0.973
ABW15005.1
PFAM: Mov34/MPN/PAD-1 family protein; KEGG: tfu:Tfu_2370 Mov34/MPN/PAD-1.
   
 0.966
ABW14246.1
PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fal:FRAAL2870 conserved hypothetical protein; putative proteasome component.
   
 0.908
ABW09874.1
PFAM: carbohydrate kinase FGGY; KEGG: fal:FRAAL4566 glycerol kinase.
   
 0.830
ABW11519.1
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
   
 0.830
ABW14972.1
Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family.
  
  
 0.621
Your Current Organism:
Frankia sp. EAN1pec
NCBI taxonomy Id: 298653
Other names: F. sp. EAN1pec
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.