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URM1 protein (Hypocrea virens) - STRING interaction network
"URM1" - Hypothetical protein in Hypocrea virens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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URM1Hypothetical protein; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2- thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target protein [...] (112 aa)    
Predicted Functional Partners:
CNXF
Hypothetical protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the p [...] (462 aa)
       
  0.938
EHK22461
Hypothetical protein (166 aa)
       
  0.806
EHK23540
Hypothetical protein (184 aa)
       
  0.701
CTU1
Hypothetical protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation (392 aa)
       
  0.669
CTU2
Hypothetical protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation (377 aa)
       
  0.666
EHK15757
Hypothetical protein (437 aa)
       
  0.622
EHK15498
Hypothetical protein (672 aa)
       
  0.579
EHK22123
Hypothetical protein (533 aa)
       
  0.541
EHK20261
Hypothetical protein (119 aa)
       
  0.541
EHK18617
Hypothetical protein (164 aa)
       
  0.541
Your Current Organism:
Hypocrea virens
NCBI taxonomy Id: 29875
Other names: Gliocladium flavofuscum, Gliocladium virens, H. virens, Hypocrea virens, Trichoderma flavofuscum, Trichoderma virens
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