STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DECR12,4-dienoyl-CoA reductase, mitochondrial. (334 aa)    
Predicted Functional Partners:
FPGS
Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.
   
 
 0.637
ECI1
Enoyl-CoA delta isomerase 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.581
ACAA1
3-ketoacyl-CoA thiolase B, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.575
LOC110481226
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial.
  
 0.572
EHHADH
Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.571
MED14
Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 
 0.541
SCP2
Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.538
FASN
Fatty acid synthase.
  
 0.531
AADAT
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial.
   
  
 0.525
SORD
Sorbitol dehydrogenase.
  
 
 0.523
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.