STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
caiCProbable crotonobetaine/carnitine-CoA ligase; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine. (522 aa)    
Predicted Functional Partners:
caiD
Carnitine racemase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.
 0.950
caiB
L-carnitine dehydratase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. Belongs to the CoA-transferase III family. CaiB subfamily.
 
  
 0.883
aroA
5-enolpyruvylshikimate-3-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
      0.866
caiA
Probable carnitine operon oxidoreductase; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family.
  
 0.851
SDY_3090
Conserved hypothetical protein; Code: IQ; COG: COG0318; orf.
 
    
0.805
caiE
Carnitine operon protein CaiE; Overproduction of CaiE stimulates the activity of CaiB and CaiD; Belongs to the transferase hexapeptide repeat family.
     
 0.778
SDY_1783
Putative oxidoreductase; Code: I; COG: COG1960.
  
 0.679
entF
ATP-dependent serine activating enzyme; May be part of enterobactin synthase as component F; Code: Q; COG: COG1020.
 
 
0.674
SDY_0068
Hypothetical protein.
  
     0.667
fadJ
Putative enzyme; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
 
 
 0.663
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
Server load: medium (72%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.