Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Predicted protein (491 aa)
Predicted Functional Partners:
Flagellar associated protein (286 aa)
Predicted protein (264 aa)
Flagellar associated protein (242 aa)
Flagellar associated protein (500 aa)
Outer row dynein assembly protein; Cilium-specific protein required for cilia structures. Axonemal dynein-associated protein that participates in a structural link between inner and outer row dyneins (209 aa)
Predicted protein (882 aa)
Flagellar/basal body protein, PACRG-like protein (219 aa)
Plasma membrane calcium ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (1009 aa)