STRINGSTRING
TOP1 protein (Chlamydomonas reinhardtii) - STRING interaction network
"TOP1" - DNA topoisomerase I in Chlamydomonas reinhardtii
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOP1DNA topoisomerase I (586 aa)    
Predicted Functional Partners:
TOP2
DNA topoisomerase II; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (1167 aa)
     
 
  0.990
TOP3
DNA gyrase subunit B-like protein; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (649 aa)
     
 
  0.953
EDP07462
Predicted protein (940 aa)
     
      0.945
EDP08003
Predicted protein (647 aa)
     
      0.928
EDP04229
Predicted protein (315 aa)
     
 
  0.912
EDP05600
DNA topoisomerase-like protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (772 aa)
       
 
  0.851
EDP00405
Predicted protein; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (644 aa)
       
 
  0.822
EDP09999
Predicted protein (424 aa)
       
 
  0.813
EDP09237
Predicted protein (192 aa)
       
  0.781
UBC3
E2 ubiquitin-conjugating enzyme (163 aa)
       
  0.781
Your Current Organism:
Chlamydomonas reinhardtii
NCBI taxonomy Id: 3055
Other names: C. reinhardtii, Chlamydomonadaceae, Chlamydomonadales, Chlamydomonas, Chlamydomonas reinhardtii, Chlamydomonas reinhardtii P.A.Dangeard, Chlamydomonas smithii, Chlamydomonas smithii R.W.Howshaw & H.Ettl, Chlorophyceae, Volvocales, Volvocida
Server load: low (8%) [HD]