Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Gamete-specific transcription factor (1035 aa)
Predicted Functional Partners:
Gamete plasma membrane protein (823 aa)
Plus agglutinin protein (559 aa)
Transcription factor, zygote-specific (183 aa)
Hypothetical protein (177 aa)
Flagellar associated protein; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed-24259666, PubMed-24574454). Involved in the control of flagellar beating in an asymmetric and planar waveform (PubMed-24259666, PubMed-24574454). Stabilizes outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1, 5 and 6 (PubMed-24259666, PubMed-24574454). Not essential for flagellar assembly (PubMed-24574454) (190 aa)
Predicted protein (665 aa)
Minus agglutinin protein (2547 aa)
Predicted protein (380 aa)
Predicted protein (376 aa)
cytosine-C5 specific DNA methyltransferase (1333 aa)