STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H0XWF3_OTOGAUncharacterized protein. (775 aa)    
Predicted Functional Partners:
ATM
Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]
    
 0.629
DYNLL1
Dynein light chain.
    
 
 0.585
DYNLL2
Dynein light chain.
    
 
 0.550
NME8
NME/NM23 family member 8.
    
 0.531
BARD1
BRCA1 associated RING domain 1.
    
  0.487
H0WY93_OTOGA
Uncharacterized protein.
    
  0.477
H0XDF7_OTOGA
Uncharacterized protein.
    
  0.477
LAMTOR2
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.
    
  0.473
DAP3
Death associated protein 3.
    
  0.469
MRPS11
Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family.
    
  0.469
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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