node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | guaB1 | jk1720 | jk1723 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | guaB2 | jk1720 | jk1722 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative inosine-5'-monophosphate dehydrogenase. | 0.999 |
guaA | hpt | jk1720 | jk0277 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.967 |
guaA | jk0499 | jk1720 | jk0499 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.954 |
guaA | jk0976 | jk1720 | jk0976 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hypothetical protein; GMP synthase - Glutamine amidotransferase domain. | 0.903 |
guaA | jk1044 | jk1720 | jk1044 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.908 |
guaA | ndk | jk1720 | jk0554 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.529 |
guaB1 | guaA | jk1723 | jk1720 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaB1 | guaB2 | jk1723 | jk1722 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Putative inosine-5'-monophosphate dehydrogenase. | 0.984 |
guaB1 | hpt | jk1723 | jk0277 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.966 |
guaB1 | jk0499 | jk1723 | jk0499 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.919 |
guaB1 | jk0976 | jk1723 | jk0976 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypothetical protein; GMP synthase - Glutamine amidotransferase domain. | 0.964 |
guaB1 | jk1044 | jk1723 | jk1044 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.903 |
guaB1 | ndk | jk1723 | jk0554 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.488 |
guaB2 | guaA | jk1722 | jk1720 | Putative inosine-5'-monophosphate dehydrogenase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaB2 | guaB1 | jk1722 | jk1723 | Putative inosine-5'-monophosphate dehydrogenase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.984 |
guaB2 | hpt | jk1722 | jk0277 | Putative inosine-5'-monophosphate dehydrogenase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.931 |
guaB2 | jk0499 | jk1722 | jk0499 | Putative inosine-5'-monophosphate dehydrogenase. | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.939 |
guaB2 | jk0976 | jk1722 | jk0976 | Putative inosine-5'-monophosphate dehydrogenase. | Hypothetical protein; GMP synthase - Glutamine amidotransferase domain. | 0.960 |
guaB2 | jk1044 | jk1722 | jk1044 | Putative inosine-5'-monophosphate dehydrogenase. | Putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.915 |