node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
coaA | coaD | jk1466 | jk1209 | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.962 |
coaA | coaE | jk1466 | jk0825 | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.522 |
coaA | dfp | jk1466 | jk1017 | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | Phosphopantothenate cysteine ligase / 4'-phospho-pantothenoyl-cysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.944 |
coaA | echA3 | jk1466 | jk1463 | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.428 |
coaA | glyA | jk1466 | jk1465 | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.692 |
coaA | panC | jk1466 | jk0286 | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | Pantoate-beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.928 |
coaA | pncA | jk1466 | jk1464 | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | Pyrazinamidase/nicotinamidase (EC 3.5.1.-) (EC 3.5.1.19) (PZAase) (Nicotine deamidase) (NAMase). | 0.618 |
coaD | coaA | jk1209 | jk1466 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | 0.962 |
coaD | coaE | jk1209 | jk0825 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.969 |
coaD | dfp | jk1209 | jk1017 | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Phosphopantothenate cysteine ligase / 4'-phospho-pantothenoyl-cysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.976 |
coaE | coaA | jk0825 | jk1466 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | 0.522 |
coaE | coaD | jk0825 | jk1209 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.969 |
coaE | dfp | jk0825 | jk1017 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Phosphopantothenate cysteine ligase / 4'-phospho-pantothenoyl-cysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.451 |
dfp | coaA | jk1017 | jk1466 | Phosphopantothenate cysteine ligase / 4'-phospho-pantothenoyl-cysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | 0.944 |
dfp | coaD | jk1017 | jk1209 | Phosphopantothenate cysteine ligase / 4'-phospho-pantothenoyl-cysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.976 |
dfp | coaE | jk1017 | jk0825 | Phosphopantothenate cysteine ligase / 4'-phospho-pantothenoyl-cysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.451 |
dfp | panC | jk1017 | jk0286 | Phosphopantothenate cysteine ligase / 4'-phospho-pantothenoyl-cysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate-beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.879 |
echA3 | coaA | jk1463 | jk1466 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase). | 0.428 |
echA3 | glyA | jk1463 | jk1465 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.616 |
echA3 | pncA | jk1463 | jk1464 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | Pyrazinamidase/nicotinamidase (EC 3.5.1.-) (EC 3.5.1.19) (PZAase) (Nicotine deamidase) (NAMase). | 0.676 |