node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACI18403.1 | guaA | DICTH_0991 | DICTH_1433 | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.526 |
ACI18403.1 | hisA | DICTH_0991 | DICTH_0997 | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977. | 0.808 |
ACI18403.1 | hisB | DICTH_0991 | DICTH_0995 | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 0.777 |
ACI18403.1 | hisC | DICTH_0991 | DICTH_0994 | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.776 |
ACI18403.1 | hisD | DICTH_0991 | DICTH_0993 | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.807 |
ACI18403.1 | hisF | DICTH_0991 | DICTH_0998 | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.809 |
ACI18403.1 | hisG | DICTH_0991 | DICTH_0992 | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.992 |
ACI18403.1 | hisH | DICTH_0991 | DICTH_0996 | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.810 |
ACI18403.1 | hisI | DICTH_0991 | DICTH_0999 | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | Histidine biosynthesis bifunctional protein hisIE; Identified by match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; match to protein family HMM TIGR03456; In the N-terminal section; belongs to the PRA-CH family. | 0.987 |
gmhA | hisA | DICTH_0555 | DICTH_0997 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977. | 0.665 |
gmhA | hisC | DICTH_0555 | DICTH_0994 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.781 |
gmhA | hisD | DICTH_0555 | DICTH_0993 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.716 |
gmhA | hisF | DICTH_0555 | DICTH_0998 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.727 |
gmhA | hisG | DICTH_0555 | DICTH_0992 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.762 |
gmhA | hisH | DICTH_0555 | DICTH_0996 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.747 |
gmhA | hisI | DICTH_0555 | DICTH_0999 | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. | Histidine biosynthesis bifunctional protein hisIE; Identified by match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; match to protein family HMM TIGR03456; In the N-terminal section; belongs to the PRA-CH family. | 0.969 |
guaA | ACI18403.1 | DICTH_1433 | DICTH_0991 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | histidyl-tRNA synthetase, putative; Identified by match to protein family HMM PF00587. | 0.526 |
guaA | hisA | DICTH_1433 | DICTH_0997 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Identified by match to protein family HMM PF00977. | 0.777 |
guaA | hisF | DICTH_1433 | DICTH_0998 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.433 |
guaA | hisH | DICTH_1433 | DICTH_0996 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.472 |