node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACI18314.1 | ACI19559.1 | DICTH_1410 | DICTH_1409 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | 0.955 |
ACI18314.1 | gcvH | DICTH_1410 | DICTH_1406 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.807 |
ACI18314.1 | gcvPA | DICTH_1410 | DICTH_1407 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.823 |
ACI18314.1 | gcvPB | DICTH_1410 | DICTH_1408 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.823 |
ACI18314.1 | gcvT | DICTH_1410 | DICTH_1405 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.838 |
ACI18623.1 | gcvPA | DICTH_0344 | DICTH_1407 | Low-specificity L-threonine aldolase; Identified by match to protein family HMM PF00266; match to protein family HMM PF01212. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.918 |
ACI18623.1 | gcvPB | DICTH_0344 | DICTH_1408 | Low-specificity L-threonine aldolase; Identified by match to protein family HMM PF00266; match to protein family HMM PF01212. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.921 |
ACI18623.1 | glyA | DICTH_0344 | DICTH_0652 | Low-specificity L-threonine aldolase; Identified by match to protein family HMM PF00266; match to protein family HMM PF01212. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
ACI19559.1 | ACI18314.1 | DICTH_1409 | DICTH_1410 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | 0.955 |
ACI19559.1 | gcvH | DICTH_1409 | DICTH_1406 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.821 |
ACI19559.1 | gcvPA | DICTH_1409 | DICTH_1407 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.829 |
ACI19559.1 | gcvPB | DICTH_1409 | DICTH_1408 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.829 |
ACI19559.1 | gcvT | DICTH_1409 | DICTH_1405 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.828 |
gcvH | ACI18314.1 | DICTH_1406 | DICTH_1410 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | 0.807 |
gcvH | ACI19559.1 | DICTH_1406 | DICTH_1409 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | 0.821 |
gcvH | gcvPA | DICTH_1406 | DICTH_1407 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
gcvH | gcvPB | DICTH_1406 | DICTH_1408 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
gcvH | gcvT | DICTH_1406 | DICTH_1405 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | glnA_1 | DICTH_1406 | DICTH_0173 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glutamine synthetase, type I; Identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; Belongs to the glutamine synthetase family. | 0.819 |
gcvH | glyA | DICTH_1406 | DICTH_0652 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |