node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACI18272.1 | ACI18789.1 | DICTH_1524 | DICTH_0536 | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | 0.402 |
ACI18272.1 | fhs | DICTH_1524 | DICTH_1527 | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.819 |
ACI18272.1 | folD | DICTH_1524 | DICTH_1526 | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.982 |
ACI18272.1 | gcvT | DICTH_1524 | DICTH_1405 | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.929 |
ACI18272.1 | glyA | DICTH_1524 | DICTH_0652 | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
ACI18272.1 | thyX | DICTH_1524 | DICTH_0644 | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.908 |
ACI18789.1 | ACI18272.1 | DICTH_0536 | DICTH_1524 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.402 |
ACI18789.1 | ACI20144.1 | DICTH_0536 | DICTH_1097 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | 5,10-methenyltetrahydrofolate synthetase; Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.920 |
ACI18789.1 | fhs | DICTH_0536 | DICTH_1527 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.936 |
ACI18789.1 | fmt | DICTH_0536 | DICTH_1334 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.911 |
ACI18789.1 | folD | DICTH_0536 | DICTH_1526 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.927 |
ACI18789.1 | gcvT | DICTH_0536 | DICTH_1405 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.924 |
ACI18789.1 | purH | DICTH_0536 | DICTH_0690 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.905 |
ACI18789.1 | purN | DICTH_0536 | DICTH_1311 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.907 |
ACI20144.1 | ACI18789.1 | DICTH_1097 | DICTH_0536 | 5,10-methenyltetrahydrofolate synthetase; Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | 0.920 |
ACI20144.1 | folD | DICTH_1097 | DICTH_1526 | 5,10-methenyltetrahydrofolate synthetase; Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
ACI20144.1 | purN | DICTH_1097 | DICTH_1311 | 5,10-methenyltetrahydrofolate synthetase; Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.914 |
fhs | ACI18272.1 | DICTH_1527 | DICTH_1524 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.819 |
fhs | ACI18789.1 | DICTH_1527 | DICTH_0536 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | 0.936 |
fhs | folD | DICTH_1527 | DICTH_1526 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.998 |