STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceAIsocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. (345 aa)    
Predicted Functional Partners:
aceB1
Malate synthase; Involved in the glyoxylate cycle which synthesizes precursors for carbohydrates from C2 compounds such as acetate. Catalyzes the Claisen condensation between acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form the malyl-CoA intermediate that is subsequently hydrolyzed to produce malate and CoA.
    
 0.994
citZ
Citrate synthase; Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle; Belongs to the citrate synthase family.
 
 0.989
citB2
Aconitate hydratase.
 
 0.955
HVO_2671
Aminotransferase class V (serine--pyruvate aminotransferase / alanine--glyoxylate aminotransferase).
  
 
 0.951
citB1
Aconitate hydratase.
 
 0.949
kdgA1
2-dehydro-3-deoxy-phosphogluconate aldolase, bacterial-type.
     
  0.900
HVO_1984A
Uncharacterized protein.
       0.773
acs1
acyl-CoA synthetase.
  
  
 0.771
acs3
acyl-CoA synthetase.
  
  
 0.771
acs5
acyl-CoA synthetase.
  
  
 0.771
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
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