STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glpRDeoR family transcription regulator GlpR; Transcriptional repressor of genes encoding both fructose and glucose metabolic enzymes such as phosphofructokinase (PFK) or 2-keto- 3-deoxy-D-gluconate kinase (KDGK) during growth on glycerol. Required for the glycerol-mediated repression of pfkB-specific transcripts, but not needed for the high-levels of the pfkB-specific transcript present when cells are grown on fructose. (255 aa)    
Predicted Functional Partners:
pfkB
1-phosphofructokinase; 1-phosphofructokinase involved in the utilization of fructose as a sole carbon and energy source; Belongs to the carbohydrate kinase PfkB family.
 
   
 0.974
kdgK1
2-keto-3-deoxygluconate kinase / 2-keto-3-deoxygalactonate kinase.
      
 0.755
ptfC
Phosphotransferase system component IIC, fructose-specific; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II PtfABC PTS system is involved in fructose transport.
 
     0.609
tif1a
Translation initiation factor aIF-1 (SUI1 protein, bacterial-type IF3); Belongs to the SUI1 family.
  
 
   0.605
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation of dihydroxyacetone (DHA). Involved, together with the DHA kinase DhaKLM, in the metabolism of DHA.
  
   
 0.599
trmB
TrmB family transcription regulator TrmB.
      
 0.596
ptfA
Phosphotransferase system component IIA, fructose-specific; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II PtfABC PTS system is involved in fructose transport.
 
     0.573
rpoL
DNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
    
   0.552
tif5B
Translation initiation factor aIF-5B (bacterial-type IF2); Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
    
   0.549
sirR
SirR/DtxR family transcription regulator SirR.
      
 0.545
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
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